Principal Scientist, iPSC Cell Therapy

Johnson & Johnson in Spring House, PA

  • Type: Full Time
position filled

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Principal Scientist, iPSC Cell Therapy located in Spring House, PA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

Essential Functions:

The Exploratory Biology group of Janssen Biotherapeutics is seeking a highly motivated and independent researcher to fill the role of Principal Scientist, iPSC Cell Therapy/CAR-T. You will function as the subject matter expert to develop novel protocols to differentiate iPSCs into therapeutic immune cells, apply state of the art gene modification strategies to support complex cell engineering approaches, and aid in formulation of the group's long-term strategy.

The successful candidate will lead a multidisciplinary team dedicated to building an iPSC platform to serve as the basis for novel engineered cell products for adoptive cell therapy in oncology and other indications. The candidate will have deep knowledge of iPSC derivation, characterization, and differentiation to immune cells, in addition to expertise in gene editing technologies (CRISPR, TALEN, ZFN, etc.). You will have a chance to create, optimize and scale a cutting-edge platform and be a leader in engineered cell therapeutics through the development of next-generation, off-the-shelf cell therapies.

Primary responsibilities:

  • Design/implement iPSC platform development and optimize differentiation of iPSCs to immune lineage cells including T cells, NK cells, etc.
  • Validate and optimize methods for multiplexed gene editing and large transgene delivery in iPSCs; identify creative, nascent solutions to address key scientific challenges required for platform success
  • Oversee generation and characterization of engineered iPSC lines to support internal programs.
  • Partner with Therapeutic Area (TA) and cell therapy teams to implement fit-for-purpose gene modification strategies and support program-specific activities.
  • Interface closely with BioTherapeutics Development (BioTD) to develop and tech transfer robust, scale-able, GMP compliant protocols for iPSC culture and differentiation
  • Closely mentor junior scientists to further develop talent within the group
  • Execute research timelines to meet program and corporate objectives
  • Foster a collaborative, creative, and rigorous culture of scientific discovery

  • Qualifications

  • Ph.D. in Biology or Immunology required
  • Minimum 7 years research experience in either iPSC biology, developmental biology, immunology, or cell and molecular biology required
  • Experience with iPSC differentiation protocols (preferably to immune subsets) required
  • Experience with gene editing methodologies (CRISPR, TALEN, ZFNs) required
  • Familiarity with gene delivery approaches (viral vectors, transposons/recombinases, homologous recombination) desirable
  • Prior experience with GMP cell bank generation desired
  • Experience with CAR-T generation and functional characterization preferred
  • Familiarity with generation and interpretation of high-dimensional datasets (single cell RNA-seq, ATAC-seq, Cytof) preferred
  • Working knowledge of protein biochemistry, basic flow cytometry or cell imaging technologies and immune cell assays required.
  • Proven ability to manage projects in a highly matrixed environment and lead cross-functional activities is required.
  • Must have excellent communication (both written and oral), time management, record keeping and data analysis and collaborative skills.

  • Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability

    Primary Location
    United States-Pennsylvania-Spring House-Welsh & McKean Roads
    Janssen Research & Development, LLC (6084)
    Job Function
    Requisition ID

    You may be interested in these similar jobs!
    School Van Driver
    Chesterbrook Academy in Macungie, PA

    Job Code: 9281Location: 733School Brand: Chesterbrook AcademyCity: MacungieSchool State: PAChesterbrook AcademyMacungie, PennsylvaniaThis is a PT pos…

    Read More
    Principal Data Scientist Artificial Intelligence Machine Learning Scientist - Financial Advice
    Vanguard in Malvern, PA

    Your Team: You will be working with a dynamic team of Innovators, AI engineers and data scientists that are at the forefront of AI/ML application for…

    Read More
    Senior Data Scientist / Artificial Intelligence / Machine Learning / AI/ML Scientist
    Vanguard in Malvern, PA

    Advance your career and our missionAs a Senior Data Scientist / Artificial Intelligence / Machine Learning / AI/ML Scientist, you will work with a hi…

    Read More
    Postdoctoral Research Fellow, Janssen, CAR T/NK
    Johnson & Johnson in Spring House, PA

    _Caring for the world, one person at a time has inspired and united the people of Johnson & Johnson for over 130 years. We embrace research and scien…

    Read More
    Scientist / Senior Scientist, Protein Sciences
    Century Therapeutics, LLC in Philadelphia, PA

    Century Therapeutics is developing novel allogeneic living cell products for oncology that overcome the limitations of current cell therapies. Centur…

    Read More
    Senior or Principal Scientist
    Absorption Systems in Exton, PA

    We are seeking a Senior Scientist (PhD)/Principal Scientist with a track record of research excellence and biological assay experience to join our Ce…

    Read More
    Principal Scientist CMC Lead
    WuXi AppTec in Philadelphia, PA

    OverviewThis is a program leadership position within Process and Technical Development department that has responsibility to lead early and late stag…

    Read More
    Principal Scientist, Non-Clinical Development
    SwanBio Therapeutics in Philadelphia, PA

    PRINCIPAL SCIENTIST, NON-CLINCAL DEVELOPMENT About SwanBio TherapeuticsSwanBio is a privately held, newly established biotechnology company focused o…

    Read More
    Res Post Doc Fellow-Laboratory of Dr. Stella Chou
    Chop in Philadelphia, PA

    LOC_ABRAMSON-Abramson BuildingReq ID:42681Shift: DaysEmployment Status:Regular - Full TimeJob SummaryThe postdoctoral fellow (postdoc) will have a te…

    Read More
    Senior Scientist/ Principal Scientist, Cell Culture Development AAV Gene Therapy
    SwanBio Therapeutics in Philadelphia, PA

    About SwanBio TherapeuticsSwanBio is a privately held, newly established biotechnology company focused on the discovery and development of innovative…

    Read More
    CAR-T Scientist
    Eurofins in Malvern, PA

    CAR-T Scientist Employee Responsibilities: Technical support of bioreactor operations and pre-culture activities in development of bioreactor process…

    Read More
    Scientist - Process Development, Cell Therapy
    WuXi AppTec in Philadelphia, PA

    OverviewIndependent scientist contributing to the development of early and late stage clinical manufacturing processes and commercial Cell Therapy ma…

    Read More
    Research Specialist C
    University of Pennsylvania in Philadelphia, PA

    Job Description Summary The Gene Therapy Program (GTP) is entering a new era of unprecedented opportunity with the great potential to reshape th…

    Read More
    Physical Therapist (PT)
    Aveanna Healthcare in Philadelphia, PA

    Physical Therapist - PediatricsAveanna HealthcareDo you want to be a part of an organization committed to its people?Do you want to be a part of a te…

    Read More
    Licensed Behavior Specialist Consultant (BSC)
    Aveanna Healthcare in Philadelphia, PA

     Behavior Specialist Consultant (BSC)Aveanna HealthcarePhiladelphia, PADo you want to be a part of an organization committed to its people?Do you wan…

    Read More